Ankylosing spondylitis is a chronic, inflammatory autoimmune disease that is a rare form of arthritis. It mainly affects the sacroiliac joints between the bones of the pelvis, and the axial skeleton, which includes the spinal column, ribcage, neck, and skull bones.
Surgery is rarely used to treat ankylosing spondylitis and most patients will not require surgical intervention. When surgery is needed, it may include:
- Joint replacement to help with severe pain or joint damage
- Fracture stabilization
- Spinal surgery
- Osteotomy
- The bone is cut to shorten, lengthen, or alter alignment
- Can correct posture, but does not fully restore mobility and flexibility
- Spinal fusion instrumentation
- Stabilizes the spine and may be used in people with spinal fractures or if significant bone has been removed during an osteotomy
- Two or more vertebrae are fused together
- Does not allow for movement of that part of the spine, but is used to fix an unstable spine
- Spinal decompression
- Osteotomy
Since most patients do not need surgery, treatment for ankylosing spondylitis usually involves a combination of exercise and physical therapy, healthy lifestyle changes, and medication.
Physical therapy and exercise used to treat ankylosing spondylitis include:
- Exercises
- Breathing exercises
- Cardiovascular
- Core strengthening
- Dynamic movements
- Fall-prevention exercises
- Isometric strengthening
- Stretching
- Posture training to help prevent the spine from becoming “frozen”
Lifestyle modifications to help manage ankylosing spondylitis include:
- Safety measures to minimize accidents caused by limited mobility
- Always wear seatbelts in motor vehicles
- Avoid contact sports and high-impact activities if the spine is inflexible
- Limit alcohol
- Modify the home to decrease the risk of falls
- Sleep on a thin pillow to help avoid developing deformities of the neck
- Use narcotics and sleeping pills with caution or avoid them entirely
- Eat a healthy diet with anti-inflammatory foods
- Don’t smoke
- Pace yourself
- Take breaks throughout the day to manage fatigue
- Support groups to help patients cope
Medications used to treat ankylosing spondylitis include:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used medications for or pain and stiffness
- Ibuprofen (Advil, Motrin)
- Naproxen (Aleve)
- Celecoxib (Celebrex)
- Diclofenac (Flector, Cambia, Zorvolex)
- Indomethacin (Indocin, Tivorbex)
- Biologics may be used if NSAIDs don’t work well
- Tumor necrosis factor-α (TNF-α) antagonists
- Adalimumab (Humira)
- Certolizumab pegol (Cimzia)
- Etanercept (Enbrel)
- Golimumab (Simponi)
- Infliximab (Remicade)
- Tumor necrosis factor-α (TNF-α) antagonists
- Anti-interleukin 17 therapy
- Ixekizumab (Taltz)
- Secukinumab (Cosentyx)
- Sulfasalazine (a DMARD) and methotrexate for arthritis symptom relief
- Corticosteroid injections for swollen, painful joints
- Opioids (narcotics) to treat pain
What Are Symptoms of Ankylosing Spondylitis?
Pain and stiffness in the lower back and buttocks characterize ankylosing spondylitis, which usually starts in late adolescence or early adulthood.
In addition to pain and stiffness, early stage ankylosing spondylitis symptoms may include:
- General discomfort
- Loss of appetite
- Mild fever
Other symptoms of ankylosing spondylitis may include:
- Irritation of soft tissues (muscles, ligaments, tendons) where they enter the bones (enthesitis), most often in extremities
- Arthritis
- Fatigue
- Bowel inflammation
- Anemia
- Eye inflammation (uveitis or iritis)
- Blurred vision
- Painful, watery, and red eyes
- Sensitivity to bright light
- Stooped posture (advanced stage)
https://www.uptodate.com/contents/axial-spondyloarthritis-including-ankylosing-spondylitis-beyond-the-basics?search=Ankylosing%20Spondylitis&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2
https://spondylitis.org/
https://www.aarda.org/diseaseinfo/ankylosing-spondylitis/
https://www.arthritis.org/diseases/ankylosing-spondylitis
https://ankylosingspondylitis.net/spinal-surgery